Platycodin D, a bioactive component of Platycodon grandiflorum, induces cancer cell death associated with extreme vacuolation
نویسندگان
چکیده
منابع مشابه
Evaluation of the Spermicidal and Contraceptive Activity of Platycodin D, a Saponin from Platycodon grandiflorum
BACKGROUND The extract of Platycodon grandiflorum has been reported to have effective spermicidal activity. This study was designed to evaluate the spermicidal and contraceptive activity, as well as the safety, of Platycodin D (PD), a major saponin in Platycodon grandiflorum. METHODS Using the computer-aided sperm analysis (CASA) test criteria, the sperm-immobilizing activity of PD was studie...
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Dendritic cell (DC) maturation is critical for initiation of the adoptive immune response. DC maturation is often attenuated in several pathological conditions including cancer. In this study, we report the effect of Platycodon grandiflorum polysaccharide (PG) on DC maturation. PG induced phenotypic maturation of DCs, as proved by the increase in the expression of CD40, CD80, CD86, and major hi...
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Platycodon grandiflorum A. DC (Campanulaceae) is a traditional medicinal plant. Its root, Platycodi Radix, contains an abundant amount of saponin glycosides, platycodins, of which platycodin D is one of the major components. The chemical structures of platycodins can be modified by various types of chemical processing, but a modification mediated with microorganisms has been not reported yet. I...
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1 Regional Innovation Center for Dental Science & Engineering, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 501-759, Korea. 2 Agricultural College of Yanbian University, Yanji 133002, Jilin, China. 3 Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. 4 Department of Cro...
متن کاملKilling cancer with platycodin D through multiple mechanisms
Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the signalling pathways have been associated with limited therapeutic success. Multi-targeted prevention of cancer ha...
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ژورنال
عنوان ژورنال: Animal Cells and Systems
سال: 2019
ISSN: 1976-8354,2151-2485
DOI: 10.1080/19768354.2019.1588163